Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an estimated incidence of 3-6 cases per 100 000 inhabitants in Sweden. There is no cure for the disease, which inevitably leads to death. A similar disease has been found among terrier dogs, with an especially high prevalence in the West Highland White Terrier (WHWT). Dogs with pulmonary fibrosis become lethargic with exercise intolerance, and in some cases they develop cough and respiratory distress. This thesis gives a brief review of the field of pulmonary fibrosis and presents a method for analyzing surfactant proteins in bronchoalveolar lavage (BAL) in the dog.

In Uganda, small scale pig production plays a major role for households to earn a living and to secure their access to meat. Piglet mortality due to diar-rhoea-related dieseases is high. In an attempt to understand the underlying causes for this high mortality this study aims to investigate the role of trans-missible gastroenteritis virus (TGEV) and is a part of a larger project con-ducted at Makerere university in Uganda. A complicating factor in this investigation is the porcine respiratory corona-virus (PRCV), a stabile mutant form of the TGE virus. The occurrence of this virus had shown to alter the impact of TGEV in e.g. Europe and North Amer-ica.

Uganda has the largest pig population in east Africa, and most of the animals are owned by smallholders. Infectious diseases among pigs have a devastating impact on the livelihood of these farmers, which are dependent on the proceeds from pig rearing. In a metagenomics study of the wild pig species bushpig (Potamochoerus larvatus), the porcine viruses Torque teno sus virus (TTSuV) 1and 2 and Porcine parvovirus 4 (PPV4) were detected. TTSuV1 and 2 are ubiquitous in the world?s swine population, and PPV4 has been found in USA and China, but neither of them has been studied in Africa previously.

Myxomatous mitral valve disease is a common disease in older dogs of small- to medium-size breeds. The mitral valve, and less commonly the tricuspid valve may be affected which causes them to leak blood from the ventricle to the atrium of the heart during systole. With increasing severity of mitral valve leakage the forward stroke volume ejected into the aorta decreases, which may lead to an increase in blood pressure in the pulmonary vein resulting in pulmonary edema. A decrease in cardiac output may lead to a decrease in blood pressure, but the body may respond in order to normalize the blood pressure. Franzén showed in 2007 that the systolic blood pressure was increased in dogs with severe mitral insufficiency.

Immune stimulating complex (iscom) matrix is a formulation that is used as anadjuvant within research. The capability of the iscom matrix to elicit an immuneresponse when not present together with an antigen has not been extensivelyinvestigated. One way to evaluate the status of the immune system is to measure theamount of cytokines that usually are produced by various cell types during an immuneresponse. The aim of the present study was to evaluate the early immune responses inporcine peripheral blood mononuclear cells (PBMC) after stimulation in vitro with theiscom matrix, AbISCO®-100. The immune response was evaluated by measuring themRNA expression for various cytokines, a chemokine receptor (CXCR4) andregulator of G-protein signaling (RGS16) in porcine PBMC after stimulation withAbISCO®-100 or other inducers like a lipopolysaccharide (LPS) and a CpGoligodeoxynucleotide (ODN 2216) used as controls.

Mykotoxinet fumonisin B1 som förekommer i hela världen på framförallt majs, har visats ge upphov till flera olika toxiska effekter hos en mängd olika djurslag. De mest specifika är leukoencefalomalaci hos häst (ELEM) och lungödem hos gris (PPE), men även skador i lever, njurar och hjärt-kärlsystemet samt carcinogenicitet har observerats. Effekterna skiljer sig en hel del mellan olika djurslag, vilket den här uppsatsen syftade att hitta möjliga anledningar till. Dessutom var syftet att sammanställa information om fumonisins verkningsmekanismer ? både bekräftade och mer osäkra sådana, samt beskriva de toxiska effekterna hos olika djur och i olika organ och även ta upp diagnosticering, vilken dos som krävs för att orsaka sjukdom samt jämföra de rekommenderade gränsvärden som har satts upp för fumonisiner i foder med forskningsresultat.

Thoroughbred racehorses have suffered from exercise-induced haemorrhage for over 300 years. Almost all competing horses develop exercise-induced pulmonary haemorrhage (EIPH) at some point but most horses don?t suffer from reduced competing capacity due to the disease. The cause of the exercise-induced haemorrhage is unknown. The most believed theory today is that EIPH is induced by pulmonary stress failure caused by pressure over 100 mmHg in the pulmonary arteries during exercise.

The progress of chronic disorders such as heart failure and chronic obstructive pulmonary disease affects various aspects of life. They have an deep impact on patients´experience of health and wellbeing and their functional qualities and quality of life. Several studies have in an extensive way described heart failure and chronic obstructive pulmonary disease in its own domain but few qualitative studies consider coexistence of the disorders from a caring science perspective. The aim was to describe the meaning of living with heart failure and chronic obstructive pulmonary disease from a lifeworld perspective. With a phenomenological and reflecting lifeworld approach it´s possible to describe eight patients daily experiences of living with severe and chronic disorders from their own narratives.

Chronic obstructive pulmonary disease can limit patients physical abilities and contribute to social isolation. The purpose of this literature study is to investigate men's and women's experiences of living with chronic obstructive pulmonary dis-ease, and the supporting and guiding role of the nurse to an increased quality of life. 13 critical reviewed articles were used to find the answers to our questions. Quality rating forms were used in order to guarantee a good scientific quality. The results show that, it is of great importance for the COPD-patients well-being to experience social support from those around them, and to have a close relation-ship with their families and friends, in order to experience quality of life.

Bakgrund: Ett stort antal personer drabbas varje år av venös tromboembolism i Sverige och ungefär en fjärdedel drabbas av lungemboli. Symtomen kan vara mycket varierande och diffusa vilket gör sjukdomen svårdiagnostiserad. De flesta patienter som kommer till sjukhus och får behandling i tid överlever. Det finns i dag mycket forskning när det gäller riskfaktorer, diagnos och behandling vid lungemboli. Däremot är inte upplevelsen av att drabbas väl studerad, inte heller hur det påverkar patientens livskvalitet.

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. The disease is the fourth leading cause of death and more than 5 percent of the adult population worldwide is affected.The aim of this study was to investigate the association between periodontitis and COPD.Search for material for the literature review was done in the medical database PubMed where the keywords were: "Chronic obstructive pulmonary disease" and "Periodontal health or periodontal disease". The result is based on twelve studies that were extracted and analyzed. The studies have investigated pocket depth, attachment loss, plaque index, bleeding on probing and bone loss. Ten studies compared a COPD group with a healthy control group, one study compared two COPD groups and one study examined a COPD group and a group with other lung diseases.Most studies found that people with COPD had a higher incidence of pocket depth, attachment loss, plaque index, bleeding on probing and bone loss.

This study had two different aims. The main aim was to investigate the dynamics and impact of African swine fever (ASF) on a farm in Uganda during a recent outbreak through a case study. The second aim was to estimate the presence of two important differential diagnoses of ASF: Classical swine fever (CSF) and Porcine Reproduction and Respiratory syndrome (PRRS).The field and laboratory based case study of the farm level dynamics of ASF virus during a recent outbreak (October-December 2010) on a farm in the district of Mityana, Uganda, was conducted, using interviews, ELISA and RT-PCR. The financial impact on the farm was also estimated. The impact of the outbreak was profound.

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a slow progressive disease affecting the family caregivers by limiting their lifestyle. Subsequently the situation can be experienced as stressful for both the afflicted and the relatives. To easier understand the needs of the caregivers of family members suffering from COPD have, it is important to get an insight into their experience of every-day life, so that medical staff can help, support and promote their health according to their needs. AIM: To illustrate caregivers? experiences of living with a family member suffering from Chronic Obstructive Pulmonary Disease.

Objective: To investigate the experiences of ambulance nurses when using Boussignac CPAPcompared to their previous model, and their suggestions for possible improvements in the use of CPAP in the care of patients with pulmonary oedema. Method: A qualitative study with a descriptive and exploratory approach. Data was collected through ten semi-structured interviews with ambulance nurses, seven men and three women. The analysis was conducted using Lundman and Graneheim?s content analysis.

SammanfattningBakgrundKronisk obstruktiv lungsjukdom orsakas ofta av rökning, vilket anses av de flesta vara en självförvållad sjukdom. Konsekvenserna av detta blir att patienter med KOL ofta upplever skuld och skamkänslor.SyfteSyftet med denna litteraturstudie är att beskriva patienters erfarenhet av skuld och skam vid kronisk obstruktiv lungsjukdom.MetodI litteraturstudien granskades åtta vetenskapliga artiklar för att få en kunskap om patienternas känslor kring sin sjukdom. Innehållsanalys användes med ett deduktivt förhållningssätt där data bearbetades för att identifiera mönster och teman.ResultatTvå huvudkategorier; skuld och skam var från början definierade och under analysen identifierades en tredje; stigmatisering. Dessa kunde senare delas in i tre olika nivåer; individ, familj/omgivning och sjukvård.KonklusionDenna studie ger sjuksköterskan en bättre förståelse för vilka känslor som kan uppstå vid en ofta självförvållad sjukdom som KOL. Den visar också vikten av att möta patienterna med empati, respekt och höja deras känsla av värdighet och moral. .